Integrated Platform Technology
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Oncalis proprietary cell-based High-Throughput Screening (HTS) for kinase inhibitors enables the rapid identification of hits with drug-like properties

Oncalis proprietary cell-based High-Throughput Screening (HTS) for kinase inhibitors is a yeast cell-based screening platform that enables functional assays to identify early "drug-like" inhibitors of Receptor Tyrosine Kinases (RTKs), cytoplasmic kinases, proteases and protein-protein interactions.

Yeast cellular systems for functional screenings combine rapidity and specificity with in vivo biological relevance.

What are the advantages of Oncalis cell-based HTS for kinase inhibitors?

  • Eukaryotic cellular environment —> hits with “drug like” properties:
    • ability to cross cell membrane
    • metabolic stability
  • Positive readout (kinase inhibitors stimulate proliferation of Oncalis genetically modified yeast strains, each strain expressing one RTK)
    • positive read-out that selects for kinase-specific inhibition and against general cytotoxicity
  • No endogenous RTKs in yeast —> high reliability and selectivity (Z' values 0.7-0.9)
  • Cost-effective assay (HTA) rapidly established for a panel of RTK
  • Identification of functional inhibitors that bind either inactive or active state kinases

Hence, Oncalis cell-based High-Throughput Screening (HTS) for kinase inhibitors reduces the time and investment usually spent on in vitro assays of molecules that must be abandoned at the "final" stage of cellular proof of concept.

How can you benefit from Oncalis cell-based HTS for RTK inhibitors?

Oncalis is offering its cell-based High-Throughput Screening (HTS) for kinase inhibitors for a fee for service. This fee is on a per-well basis.

The HTS can be pan-hits (i.e. screening of numerous hits for selected kinases) or pan-kinases (i.e. screening of limited number of hits for all or a large panel of kinases).

For information or offer contact:

 

Oncalis AG

Biotech Center Zurich

Wagistr. 21
CH-8952 Schlieren
Mail: info@oncalis.com
Phone: +41-44-733 4900/03